{"id":49123,"date":"2026-02-23T20:00:02","date_gmt":"2026-02-23T20:00:02","guid":{"rendered":"https:\/\/uomosul.edu.iq\/en\/science\/?p=49123"},"modified":"2026-06-24T17:47:02","modified_gmt":"2026-06-24T17:47:02","slug":"phd-dissertation-defense-in-the-department-of-chemistry-discusses-the-preparation-of-metal-complexes-derived-from-non-steroidal-drugs-and-the-evaluation-of-their-biological-activity","status":"publish","type":"post","link":"https:\/\/uomosul.edu.iq\/en\/science\/2026\/02\/23\/phd-dissertation-defense-in-the-department-of-chemistry-discusses-the-preparation-of-metal-complexes-derived-from-non-steroidal-drugs-and-the-evaluation-of-their-biological-activity\/","title":{"rendered":"PhD Dissertation Defense in the Department of Chemistry Discusses the Preparation of Metal Complexes Derived from Non-Steroidal Drugs and the Evaluation of Their Biological Activity"},"content":{"rendered":"
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The Department of Chemistry at the College of Science, University of Mosul, witnessed on Monday, February 23, 2026, the defense of the PhD dissertation submitted by doctoral candidate Faihaa Kamal Hussein Al-Jarrah<\/strong>, entitled:<\/p>\n

\u201cPreparation and Characterization of Some Metal Complexes with Hydrazone Ligands Derived from Certain Non-Steroidal Drugs and Evaluation of Their Biological Activity.\u201d<\/strong><\/p>\n

The dissertation aimed to prepare and characterize complexes of divalent transition metal ions derived from hydrazone ligands, investigate their structural and physicochemical properties, and evaluate their biological activity. The study was further supported by theoretical investigations using Density Functional Theory (DFT)<\/strong> and molecular docking analyses<\/strong> to explore their potential applications in the biomedical and pharmaceutical fields.<\/p>\n

The research involved the synthesis of seventy metal complexes<\/strong> using cobalt(II), nickel(II), copper(II), zinc(II), and cadmium(II) salts through reactions of metal chlorides and nitrates with ten hydrazone ligands prepared via hydrazone condensation reactions.<\/p>\n

Advanced analytical techniques were employed to characterize the synthesized ligands and complexes, including UV-Visible spectroscopy<\/strong>, \u00b9H-NMR spectroscopy<\/strong>, infrared (IR) spectroscopy<\/strong>, and CHN elemental analysis<\/strong>. Additional analyses included metal content determination using atomic absorption spectroscopy<\/strong>, measurements of molar electrical conductivity<\/strong>, magnetic susceptibility<\/strong>, and powder X-ray diffraction (XRD)<\/strong> for selected complexes. Computational studies based on DFT<\/strong> and molecular docking were also conducted for selected ligands, alongside antioxidant activity assays and antibacterial evaluations using the agar well diffusion method.<\/p>\n

The findings revealed varying inhibitory activities of several synthesized ligands and complexes against the Gram-negative bacterium Escherichia coli<\/strong> and the Gram-positive bacterium Staphylococcus aureus<\/strong>, indicating promising potential for the development of biologically active compounds.<\/p>\n

Chemical and physical analyses demonstrated that the ten ligands behaved as neutral bidentate ligands coordinating through the azomethine nitrogen atom and the carbonyl oxygen atom. The metal ions exhibited coordination numbers of four and six<\/strong>, with octahedral geometries predominating among six-coordinate complexes, while four-coordinate complexes adopted either square-planar<\/strong> or tetrahedral<\/strong> geometries.<\/p>\n

The examination committee was chaired by Professor Dr. Jasim Mohammed Al-Elias<\/strong> and included:<\/p>\n