{"id":51628,"date":"2026-08-24T08:17:16","date_gmt":"2026-08-24T08:17:16","guid":{"rendered":"https:\/\/uomosul.edu.iq\/en\/science\/?p=51628"},"modified":"2026-08-26T08:34:16","modified_gmt":"2026-08-26T08:34:16","slug":"doctoral-dissertation-discusses-the-preparation-diagnosis-and-theoretical-study-of-new-complexes-derived-from-heterocyclic-ligands","status":"publish","type":"post","link":"https:\/\/uomosul.edu.iq\/en\/science\/2026\/08\/24\/doctoral-dissertation-discusses-the-preparation-diagnosis-and-theoretical-study-of-new-complexes-derived-from-heterocyclic-ligands\/","title":{"rendered":"Doctoral dissertation discusses the preparation, diagnosis and theoretical study of new complexes derived from heterocyclic ligands"},"content":{"rendered":"

The Department of Chemistry at the Faculty of science at the University of Mosul discussed the doctoral thesis tagged\u201d preparation, diagnosis and theoretical study of new complexes derived from heterocyclic ligands with transitional and main elements and evaluating their biological effectiveness \u201d on Monday, August 24, 2026, attended by the dean of the Faculty, Professor Dr. Hiam Adel Ibrahim, the Scientific Assistant, the head of the department and a number of graduate students.<\/span> The thesis submitted by the student (Saba Mumtaz Saleh al-Asali) from the branch of inorganic chemistry dealt with the preparation and diagnosis of fifty new harmonic complexes, as well as the synthesis of five basic ligands.<\/span> The work<\/span> was divided<\/span> into<\/span> two stages<\/span>: The first stage included the organic part<\/span>: preparation<\/span> of five<\/span> heterocyclic chelating ligands(L1-L5) .<\/span> The second stage included the inorganic part<\/span>: the preparation of coordination<\/span> complexes<\/span> of<\/span> these ligands<\/span> with different<\/span> molar<\/span> ratios<\/span> between<\/span> the ligand<\/span> and the metal<\/span> ion<\/span>(2L1:1m), (2L1:2m), (Ln: M) and(2ln:1m) using metal salts mn (II), Co(II), Ni(II), Cu(II) and Zn (II), resulting in complexes with new formulas.<\/span> Lycands<\/span> and their complexes<\/span> were diagnosed<\/span> using<\/span> multiple<\/span> techniques<\/span>, including<\/span> microarray analysis<\/span>, spectroscopy (infrared, electron Spectra, NMR Proton spectrum), as well as measurements of magnetic sensitivity and molar electrical conductivity.<\/span>Also, some theoretical computational measurements were carried out using the density function (DFT) of the prepared ligands and complexes as well as the measurement of antibacterial efficacy to assess the biological effectiveness of both prepared lycands and complexes against two types of bacteria: Escherichia coli and staphylococcus aureus.<\/span> The results<\/span> showed<\/span> a remarkable<\/span> inhibitory<\/span> activity<\/span> of metal complexes, especially<\/span> copper<\/span> complexes<\/span> belonging<\/span> to L4<\/span> and<\/span> L5<\/span>, compared<\/span> to free<\/span> ligands<\/span>, exceeding<\/span> the<\/span> inhibition diameters<\/span> of reference standard antagonists (Cefotaxime) and (Ampicillin), indicating the possibility of their future use in Pharmacological applications.<\/span>The study also included the assessment<\/span> of biochemical<\/span> effects<\/span> using<\/span> (80<\/span>) white<\/span> male<\/span> mice<\/span> in which renal<\/span> cell<\/span> carcinoma<\/span> was chemically<\/span> induced<\/span> by injection<\/span> with (N-Nitrosodimethylamine) NDMA for<\/span> four<\/span> months<\/span>, the affected group was treated with peritoneal injections<\/span> of lindane<\/span> L3<\/span> and<\/span> L5<\/span> and their complexes<\/span> [ZnL3Cl2<\/span>] and [CuL5Cl2<\/span>] in three doses (0.5, 1, 1.5 mg\/kg)for 21 days.<\/span> Biochemical<\/span> evaluation<\/span> of blood serum<\/span> showed<\/span> a significant<\/span> significant<\/span> decrease<\/span> (p\u22640.05) in the levels of renal inflammatory and tumor indicators (COX-2, TNF-\u03b1, IL-6, LOX-2) and optimal therapeutic efficiency was recorded at dose concentration (1 mg\/kg).<\/span> These<\/span> results<\/span> matched<\/span> the histopathological<\/span> examination<\/span> of the treated kidney tissue, in which a sharp regression of tumor-like cells was observed with the restoration of the normal histological structure of the glomeruli and renal tubules.<\/span> Discussion<\/span> Committee<\/span>: Prof.<\/span> Dr. sohaba<\/span> Ali<\/span> Ahmed<\/span>-chairman<\/span> Assistant<\/span> professor<\/span> Dr.<\/span> Leila<\/span> Juma<\/span> Najm<\/span>-member<\/span> Assistant<\/span> professor<\/span> Dr. Mounira<\/span> Youssef<\/span> Raouf<\/span>-member<\/span> Assistant<\/span> professor<\/span> Dr. Samaa<\/span> Adnan<\/span> Rauf<\/span>-member<\/span> Assistant<\/span> professor<\/span> Dr. Alia<\/span> Sabah<\/span> Mohammed<\/span>-member<\/span> Assistant<\/span> professor<\/span> Dr. Farah<\/span> Tarek<\/span> Saeed<\/span>-member<\/span> and supervisor<\/span> Assistant<\/span> professor<\/span> Dr. Haifa<\/span> Younis<\/span> Hussein<\/span>-member<\/span> and supervisor<\/span> The dean of the Faculty, Professor Dr. Hiam Adel Ibrahim, presented a<\/span> letter<\/span> of thanks<\/span> and appreciation<\/span> to<\/span> Dr. Samaa<\/span> Adnan<\/span> Rauf<\/span> \/ northern<\/span> Technical<\/span> University<\/span> appreciating<\/span> her efforts<\/span> in participating<\/span> in the student discussion<\/span> We wish<\/span> the<\/span> students and teachers of our college continued<\/span> progress<\/span> and prosperity<\/span><\/p>\n

Government information and Communication Division<\/span><\/p>\n

Monday<\/span>, August 24, 2026<\/span><\/p>\n

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 <\/p>\n","protected":false},"excerpt":{"rendered":"

The Department of Chemistry at the Faculty of science at the University of Mosul discussed the doctoral thesis tagged\u201d preparation, diagnosis and theoretical study of new complexes derived from heterocyclic ligands with transitional and main elements and evaluating their biological effectiveness \u201d on Monday, August 24, 2026, attended by the dean of the Faculty, Professor Dr. Hiam Adel Ibrahim, the Scientific Assistant, the head of the department and a number of graduate students. The thesis submitted by the student (Saba Mumtaz Saleh al-Asali) from the branch of inorganic chemistry dealt with the preparation and diagnosis of fifty new harmonic complexes, as [Read More]<\/a><\/p>\n","protected":false},"author":21,"featured_media":51629,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-51628","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/uomosul.edu.iq\/en\/science\/wp-json\/wp\/v2\/posts\/51628","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/uomosul.edu.iq\/en\/science\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/uomosul.edu.iq\/en\/science\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/uomosul.edu.iq\/en\/science\/wp-json\/wp\/v2\/users\/21"}],"replies":[{"embeddable":true,"href":"https:\/\/uomosul.edu.iq\/en\/science\/wp-json\/wp\/v2\/comments?post=51628"}],"version-history":[{"count":1,"href":"https:\/\/uomosul.edu.iq\/en\/science\/wp-json\/wp\/v2\/posts\/51628\/revisions"}],"predecessor-version":[{"id":51639,"href":"https:\/\/uomosul.edu.iq\/en\/science\/wp-json\/wp\/v2\/posts\/51628\/revisions\/51639"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/uomosul.edu.iq\/en\/science\/wp-json\/wp\/v2\/media\/51629"}],"wp:attachment":[{"href":"https:\/\/uomosul.edu.iq\/en\/science\/wp-json\/wp\/v2\/media?parent=51628"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/uomosul.edu.iq\/en\/science\/wp-json\/wp\/v2\/categories?post=51628"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/uomosul.edu.iq\/en\/science\/wp-json\/wp\/v2\/tags?post=51628"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}