{"id":1231,"date":"2014-06-05T00:00:00","date_gmt":"2014-06-04T21:00:00","guid":{"rendered":"https:\/\/uomosul.edu.iq\/science\/2014\/06\/05\/%d8%ac%d8%b1%d8%aa-%d9%81%d9%8a-%d9%82%d8%b3%d9%85-%d8%b9%d9%84%d9%88%d9%85-%d8%a7%d9%84%d8%ad%d9%8a%d8%a7%d8%a9-%d9%83%d9%84%d9%8a%d8%a9-%d8%a7%d9%84%d8%b9%d9%84%d9%88%d9%85-%d9%85%d9%86%d8%a7-7\/"},"modified":"2014-06-05T00:00:00","modified_gmt":"2014-06-04T21:00:00","slug":"%d8%ac%d8%b1%d8%aa-%d9%81%d9%8a-%d9%82%d8%b3%d9%85-%d8%b9%d9%84%d9%88%d9%85-%d8%a7%d9%84%d8%ad%d9%8a%d8%a7%d8%a9-%d9%83%d9%84%d9%8a%d8%a9-%d8%a7%d9%84%d8%b9%d9%84%d9%88%d9%85-%d9%85%d9%86%d8%a7-7","status":"publish","type":"post","link":"https:\/\/uomosul.edu.iq\/science\/%d8%ac%d8%b1%d8%aa-%d9%81%d9%8a-%d9%82%d8%b3%d9%85-%d8%b9%d9%84%d9%88%d9%85-%d8%a7%d9%84%d8%ad%d9%8a%d8%a7%d8%a9-%d9%83%d9%84%d9%8a%d8%a9-%d8%a7%d9%84%d8%b9%d9%84%d9%88%d9%85-%d9%85%d9%86%d8%a7-7\/","title":{"rendered":"\u062c\u0631\u062a \u0641\u064a \u0642\u0633\u0645 \u0639\u0644\u0648\u0645 \u0627\u0644\u062d\u064a\u0627\u0629 \/ \u0643\u0644\u064a\u0629 \u0627\u0644\u0639\u0644\u0648\u0645 \u0645\u0646\u0627\u0642\u0634\u0629 \u0627\u0637\u0631\u0648\u062d\u0629 \u0637\u0627\u0644\u0628\u0629 \u0627\u0644\u062f\u0643\u062a\u0648\u0631\u0627\u0647 &quot; \u0635\u0641\u0627\u0621 \u0639\u0628\u062f \u0627\u0644\u0639\u0632\u064a\u0632 \u0627\u0644\u0627\u0645\u064a\u0646 &quot; \u0648\u062d\u0635\u0644\u062a \u0639\u0644\u0649 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0625\u0633\u062a\u0646\u062a\u0627\u062c\u0627\u062a"},"content":{"rendered":"<p>\u062c\u0631\u062a \u0641\u064a \u0642\u0633\u0645 \u0639\u0644\u0648\u0645 \u0627\u0644\u062d\u064a\u0627\u0629 \/ \u0643\u0644\u064a\u0629 \u0627\u0644\u0639\u0644\u0648\u0645 \u0645\u0646\u0627\u0642\u0634\u0629 \u0627\u0637\u0631\u0648\u062d\u0629 \u0637\u0627\u0644\u0628\u0629 \u0627\u0644\u062f\u0643\u062a\u0648\u0631\u0627\u0647 &quot; \u0635\u0641\u0627\u0621 \u0639\u0628\u062f \u0627\u0644\u0639\u0632\u064a\u0632 \u0627\u0644\u0627\u0645\u064a\u0646 &quot; \u0648\u0627\u0644\u0645\u0648\u0633\u0648\u0645\u0629 &quot; Biochemical Study of Autism Spectrum Disorder Patients &quot; \u0648\u062d\u0635\u0644\u062a \u0639\u0644\u0649 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0625\u0633\u062a\u0646\u062a\u0627\u062c\u0627\u062a<em> <u>It was concluded from the present study that:<\/p>\n<ul>\n<li>Autism spectrum disorder seems to occur in males more than females <em>(~ 5 male to 1 female ratio in Mosul city).\n<li><em>Oxidative stress with environmental toxicants exposure might be considered as a risk factor in ASD. This depended upon several biochemical parameters and enzymatic activities especially in severe ASD group.\n<li>A <em><u>significant reduction was detected in MEL, NGB, AOA, GSH concentrations in severe ASD group compared to control group. In addition, a <em><u>significant increase in TBARS, AOPP, NO concentration were shown in the severe ASD group.\n<li><em>Furthermore, a <u>significant reduction in DPP-4, AChE GST, aryl esterase <em>activities were observed in severe ASD group.\n<li>Dipeptidyl peptidase-4 could be a good marker in some individuals with ASD especially in those having gastrointestinal disorders and various inflammations.\n<li>Two proteinous components had been isolated by gel filtration chromatography (sephadex G100). It was found that the first peak only (peak A) had a high DPP-4 activity of normal human serum. As well, the first peak of proteinous precipitate of patient urine had a high activity of DPP-4.\n<li><em>The comparative<em>molecular weight <em>of serum DPP-4 was (176.6, 170.4) KD by gel filtration and SDS-PAGE techniques respectively, while DPP-4 of patient urine was232.6 KD by gel <em>filtration <em>chromatography.\n<li>A single peak of normal serum DPP-4 was obtained from RP-HPLC technique.\n<li>Using glycine proline-p-nitro anilide hydrochloride as a substrate, Km and Vmax of normal human serum DPP-4 were 0.5 mM and 50 &mu;M respectively.\n<li>Mercury chloride and strontium chloride as toxicant metals inhibited DPP-4 activity by 30.2% and 42.9% respectively.<br \/>\n","protected":false},"excerpt":{"rendered":"<p>\u062c\u0631\u062a \u0641\u064a \u0642\u0633\u0645 \u0639\u0644\u0648\u0645 \u0627\u0644\u062d\u064a\u0627\u0629 \/ \u0643\u0644\u064a\u0629 \u0627\u0644\u0639\u0644\u0648\u0645 \u0645\u0646\u0627\u0642\u0634\u0629 \u0627\u0637\u0631\u0648\u062d\u0629 \u0637\u0627\u0644\u0628\u0629 \u0627\u0644\u062f\u0643\u062a\u0648\u0631\u0627\u0647 &quot; \u0635\u0641\u0627\u0621 \u0639\u0628\u062f \u0627\u0644\u0639\u0632\u064a\u0632 \u0627\u0644\u0627\u0645\u064a\u0646 &quot; \u0648\u0627\u0644\u0645\u0648\u0633\u0648\u0645\u0629 &quot; Biochemical Study of Autism Spectrum Disorder Patients &quot; \u0648\u062d\u0635\u0644\u062a \u0639\u0644\u0649 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0625\u0633\u062a\u0646\u062a\u0627\u062c\u0627\u062a It was concluded from the present study that: Autism spectrum disorder seems to occur in males more than females (~ 5 male to 1 female ratio in Mosul city). Oxidative stress with environmental toxicants exposure might be considered as a risk factor in ASD. This depended upon several biochemical parameters and enzymatic activities especially in severe ASD group. A significant reduction was detected in MEL, NGB, AOA, GSH <a href=\"https:\/\/uomosul.edu.iq\/science\/%d8%ac%d8%b1%d8%aa-%d9%81%d9%8a-%d9%82%d8%b3%d9%85-%d8%b9%d9%84%d9%88%d9%85-%d8%a7%d9%84%d8%ad%d9%8a%d8%a7%d8%a9-%d9%83%d9%84%d9%8a%d8%a9-%d8%a7%d9%84%d8%b9%d9%84%d9%88%d9%85-%d9%85%d9%86%d8%a7-7\/\"> [\u0625\u0642\u0631\u0623 \u0627\u0644\u0645\u0632\u064a\u062f]<\/a><\/p>\n","protected":false},"author":1,"featured_media":1232,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-1231","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-2"],"_links":{"self":[{"href":"https:\/\/uomosul.edu.iq\/science\/wp-json\/wp\/v2\/posts\/1231","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/uomosul.edu.iq\/science\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/uomosul.edu.iq\/science\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/uomosul.edu.iq\/science\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/uomosul.edu.iq\/science\/wp-json\/wp\/v2\/comments?post=1231"}],"version-history":[{"count":0,"href":"https:\/\/uomosul.edu.iq\/science\/wp-json\/wp\/v2\/posts\/1231\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/uomosul.edu.iq\/science\/wp-json\/wp\/v2\/media\/1232"}],"wp:attachment":[{"href":"https:\/\/uomosul.edu.iq\/science\/wp-json\/wp\/v2\/media?parent=1231"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/uomosul.edu.iq\/science\/wp-json\/wp\/v2\/categories?post=1231"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/uomosul.edu.iq\/science\/wp-json\/wp\/v2\/tags?post=1231"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}