College of Education for Pure Science

Master’s Thesis Viva in the College of Education for Pure Science entitled “Synthesis of heterocyclic compounds by cyclization of imines and studying the biological activity of the resulting compounds and comparing them with known pharmaceutical compounds”The College of Education for Pure Science, University of Mosul, has done the master’s thesis viva entitled “Synthesis of heterocyclic compounds by cyclization of imines and studying the biological activity of the resulting compounds and comparing them with known pharmaceutical compounds “,On Tuesday, May 10, 2022, the college staff including the respected Dean of the College, Assistant Professor Dr. Qais Ismail Ibrahim, the Honorable Scientific Associate and Administrative Associate, the Honorable Head of the Department of chemistry, and a number of the college’s teachers were attended the viva.This study, presented by the Msc. student Ahmed Mahdi Salih in the Department of Chemistry, In this research, the synthesis and identification of a number of compounds from heterocyclic compounds, starting with the quaternary ring as substitutes of azitidine-2-on and five-cyclic such as the thiazolidine-4- and tetrazole substitutes, in addition to the substitutes of the 7,4-oxypine-7,4-dione using rules Schiff and hydrazones as intermediates for reactions.The first course It included the preparation of a number of Schiff base compounds (A1-6) by reacting aromatic benzaldehyde or ketone substitutes with amines and then cyclizing these compounds by α-chloroacetyl chloride to form derivatives of the tetracyclic azetidine-2-un (A7-12), as In this pathway, the derivatives of the thiazolidine-4-on (penta ring) (A13-18) were prepared from the reaction of Schiff’s bases with thioglycolic acid, as well as the cyclization of Schiff’s bases compounds by sodium azide to prepare tetrazol derivatives (A19-22), creating the seven-ring oxazepine, 4- di-on (A25-36) from the reactance of Schiff bases with maleic anhydride and phthalic anhydride.The second path: This path included the preparation of a number of hydrazones (A45-49) from the reaction of substituted benzaldehyde with decanoic acid hydrazide (A44) through their reactance with different cyclic reagents, where they were reacted with α-chloroacetyl chloride to prepare substituted azitidine-2- Un (A50-54) and its reaction with glycolic acid to synthesize the derivatives of thiazolidine-4-(A55-59), and through the reaction of hydrazones with sodium azide, we get substitutes for trazole (A60-64), and the derivatives of oxazepine-7,4-Dione were created. (A65-74) from reacting the hydrazones (A 44) with maleic anhydride once and phthalic anhydride again.The third path: In this path, the pyrazole-3-on derivative (A75) was prepared from the reaction of decanoic acid hydrazide (A44) with ethyl acetoacetate, and then the pyrazole-3-on derivative was reacted with benzaldehyde substitutes to obtain chalcon (A76-80).The fourth pathway: In this pathway, a derivative 1,2-bis(4-methoxybenzylidene)hydrazine (A81) was prepared from the reaction of multiple moles of 4-methoxybenzaldehyde with aqueous hydrazine, after which it was reacted with Schiff bases compounds (A1-6) to form Formation of 1,2,4-triazine derivatives with a Diels-Alder like reaction (A82-86).The identity of the prepared compounds was also determined using physical constants and spectroscopic methods (infrared and nuclear magnetic resonance spectroscopy) and the biological activity was evaluated in veterinary laboratories using two types of gram-positive and gram-negative bacteria.The discussion committee was chaired by Prof. Dr. Eyad Saadi Hamid Tikrit University / College of Science and the membership of Asst. Prof. Dr. Shaker Mahmoud Saeed College of Al-Noor University, Assistant Professor Dr. Anwar Abed Al-Ghani University of Mosul/College of Education for Pure Sciences and under the supervision and membership of Asst. Prof. Dr. Muhannad Yaqzan Saleh from Mosul University/College of Education for Pure Sciences /Chemistry Department.