College of Science

The tagged doctoral thesis was discussed at the Department of Chemistry at the College of Science / University of Mosul:

“Evaluation Of Sirtuin 3 And Tyrosine Hydroxylase And Their Association With Certain Biochemical Parameters In The Serum Of Parkinson Disease Patients And Studying The Effect of Some Natural Isolated Products”

Presented by student Khaled Mohammed Khader Abbas, on Sunday 23 / 11 / 2025, in the presence of the administrative assistant, Assistant Prof. Dr. Omar Adel Sharif, and a number of College teachers and graduate students.

The thesis focuses on the study of the vital role of Sirtuin-3 enzyme in Parkinson’s patients through the analysis of enzyme levels and a set of biomarkers associated with the disease. The study involved 180 male and female participants, half of whom had Parkinson’s, in which the levels of a wide range of indicators were measured such as: tyrosine hydroxylase, dopamine, alpha-synuclein, tau protein, beta-amyloid, inflammatory factors TNF-α and YL-6, iron, zinc, magnesium, copper, malondialdehyde, and clotathione, along with electrolyte and uric acid assays.

The results of the study showed a clear decrease in the levels of Sirtuin 3, tyrosine hydroxylase, dopamine, and clotathione in patients, against a significant increase in alpha-synuclein, tau protein, beta-amyloid, TNF-α, IL-6, iron, zinc, copper, and malondialdehyde, while no significant differences were recorded in the levels of electrolytes and uric acid. The results also indicated higher levels of tau protein and iron in males compared to females, while the age group from 71 to 85 years was the most affected and changed in indicators, which indicates its correlation with the degree of development of neurodegenerative diseases.

The thesis also included the isolation and purification of the Sirtuin 3 enzyme from the serum of patients and healthy people, where the results showed a difference in molecular weight, amounting to 62.5 KD in patients compared to 65.1 KD in healthy people. The gene expression of the enzyme was also analyzed using Real-time PCR technology, and the results showed a severe decrease in the gene expression of Sirtuin-3 in Parkinson’s patients, which strengthens the hypothesis of its protective role in countering oxidative stress and mitochondrial myopathy.

The discussion committee consisted of:

Prof. Dr. Nadia Ahmed Saleh Mohammed (Chairman)،

Prof. Dr. Zahra Mohamed Ali hammoudat (member)،

Prof. Dr. Lama Abdel Moneim Bakr al-Dabbagh (member)،

Assistant prof. Dr. Mohammed Fadel Hamid (member)،

Assistant prof. Dr. Safa Abdul Aziz Taha (member)،

Under the supervision of assistant professor Dr. Mohammed Bahri Hassan.

At the end of the discussion, the administrative assistant and on behalf of the dean of the College, Prof. Dr. Hiyam Adel Ibrahim, presented a letter of thanks and appreciation to Prof. Dr. Nadia Ahmed Saleh Mohammed from the College of education for Pure Sciences / University of Tikrit, in appreciation of her scientific efforts and active participation in the discussion.

We wish our dear students continued success and success.

Government information and Communication Division

Sunday, November 23, 2025