Master Thesis Viva _ Chemistry Department
Master thesis Viva in the College of Education for Pure Science entitled ” Synthesis of Some 2- amino 1,3,4-thiadiazole drivatives and Study of their Biological activity ”
The College of Education for Pure Science, University of Mosul, has done the Master thesis Viva entitled ” Synthesis of Some 2- amino 1,3,4-thiadiazole drivatives and Study of their Biological activity “,
On Tuesday, September 5, 2023, the College staff including the respected Dean of the College, Assistant Professor Dr. Qais Ismail Ibrahim, the Honorable Scientific Associate and Administrative Associate, the Honorable Head of the Department of Chemistry, and a number of the college’s teachers were attended the viva.
In this study, presented by the master student Ayad Abdullah Abdulrahman Al-bdrani in the Department of Chemistry, the compounds A2, A4 and A5 obtained through the reaction of aldehyde with thiosimecarbazide or through the reaction of carboxylic acid with thiosimecarbazide were chosen as basic raw materials because of their biological importance and importance in several fields, especially in organic chemistry, because they have a group of chemical structures (NH2) is effective and can transform or bind with other compounds, as different types of compounds were prepared by the traditional method, and some of the prepared compounds are intermediate compounds, from which a number of other new derivatives were prepared.
Compounds (A6-A26) were obtained from Schiff bases by reacting with aromatic monocarbonyls (aldehydes, ketones) or dicarbonyl ketones (aliphatic or aromatic). A section of Schiff bases were converted into heterocyclic compounds by reacting them with [sodium azide, anhydrides (phthalic, succinic and malic), glycine and thiocyclic acid] to give compounds (A25-A42).
In another reaction of the amine group, imide derivatives (A44, A43) were obtained by reacting with anhydrides (phthalic, succinic) and dicarbonyl amides were obtained from the reaction of compound A5 with ethyl acetoacetate or benzoyl ethyl acetate to give compounds A45 and A46 And through the interaction of the compound (A44) with aromatic aldehydes, unsaturated carbonyl compounds (A47 and A48) were obtained, which were reacted with hydrazine or thiourea to obtain pyrazole and pyrimidine thiones (A49 – A52).
And when the two compounds (A47 and A48) were reacted with thiourea aromatic aldehydes or quinidine hydrochloride in a beginelli type reaction to give pyrimidine derivatives (A53-A56).
On the other hand, the amine group of the two compounds (A2 and A5) was converted to diazonium salt, which was reacted with dicarbonyl compounds (benzoyl acetone, ethyl acetoacetate and benzoyl ethyl acetate) in the presence of sodium acetate to give compounds (A57-A62). And through the condensation of the resulting compounds with hydrazine or phenylhydrazine, derivatives of parazole and pyrazolone compounds (A74-A63) were obtained.
The structural formulas of the compounds prepared were confirmed by different physical and spectroscopic methods (IR, UV, 1H-NMR, 13C-NMR).
Finally, a biological activity test (preliminary biological evaluation) was conducted for a number of prepared compounds, and all types of bacteria showed resistance towards some of the compounds that were chosen, but the small number of these compounds showed good efficacy towards them.
The Viva committee was chaired by Prof. Dr. Rafid Kamal Jameel / Al-Noor University- College and the membership of Asst. Prof. Dr. Omar Thnoun Ali / University of Mosul / College of Education for Pure Science, Asst. Prof. Dr. Harith Mohammed Salman / University of Mosul / College of Science, and under the supervision and membership of Assist. Prof. Dr. Jasim Ali Abdullah / University of Mosul / College of Education for Pure Science.