14 September، 2025

A Research Team from the Department of Biology Registers Twelve Gene Mutations in the Global Gene Bank (NCBI)

In a new scientific achievement added to the record of the College of Science – University of Mosul, Asst. Prof. Dr. Haitham Luqman Shihab Al-Hayali, Dr. Mowafaq Khalil Hassan Al-Masri, faculty members in the Department of Biology, along with PhD student Shaimaa Ubaid Mustafa, successfully registered twelve gene mutations in the Global Gene Bank (NCBI).

The registered mutations are listed under the following codes and accession numbers:

  • HSHM, Obaid7HM, Obaid8HM, SHHM, Obaid9HM, Obaid3HM, Obaid4HM, Obaid2HM, MSHH, Obaid5HM, Obaid6HM

  • mutS-like protein 6 transcript variant 1 (MSH6) mRNA (PV505826)

  • BRCA1 DNA repair associated protein 1 transcript variant 1 (BRCA1) mRNA (PV505828)

  • KRAS proto-oncogene GTPase transcript variant b (KRAS) mRNA (PV558321)

  • APC regulator of WNT signaling pathway transcript variant 3 (APC) mRNA (PV505827)

  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) mRNA (PV530381)

  • KRAS proto-oncogene GTPase transcript variant b (KRAS) mRNA (PV477844)

  • phosphatase and tensin-like protein (PTEN) mRNA (PV491913)

  • BRCA2 DNA repair associated protein (BRCA2) mRNA (PV491914)

  • phosphatase and tensin-like protein (PTEN) mRNA (PV296016)

  • tumor protein p53 transcript variant 1 (TP53) mRNA (PV505825)

  • phosphatase and tensin-like protein (PTEN) mRNA (PV505824)

  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) mRNA (PV491915)

The registered mutations include:

  • Two mutations in the PIK3CA gene (and protein sequence)

  • One mutation in the BRCA1 gene (and protein sequence)

  • Two mutations in the KRAS gene (and protein sequence)

  • One mutation in the APC gene (and protein sequence)

  • One mutation in the MSH6 gene (and protein sequence)

  • Three mutations in the PTEN gene (and protein sequence)

  • One mutation in the BRCA2 gene (and protein sequence)

  • One mutation in the TP53 gene (and protein sequence)

The samples were collected from patients with colon cancer who were examined by specialized physicians. This achievement represents a significant contribution to enriching global genetic databases and reflects the research efforts of the Department of Biology in the fields of Biochemistry, Molecular Biology, and Genetics.

We wish our faculty members and students continued success in their scientific and academic endeavors.

Share

Share