College of Education for Pure Science

PH.D. Dissertation Viva in the College of Education for Pure Science entitled ” Synthesis and study of a number of compounds and polymers heterocyclic and evaluation biological activity “The College of Education for Pure Science, University of Mosul, has done the PH.D. Dissertation Viva entitled ” Synthesis and study of a number of compounds and polymers heterocyclic and evaluation biological activity “,On Thursday, March 9, 2023, the College staff including the respected Dean of the College, Assistant Professor Dr. Qais Ismail Ibrahim, the Honorable Scientific Associate and Administrative Associate, the Honorable Head of the Department of Chemistry, and a number of the college’s teachers were attended the viva. In this study, presented by the PH.D. Student Azhar Hussein Ali in the Department of Chemistry, the compound (indole-3-butyric acid) was used as a starting material in the preparation and study of a number of heterocyclic compounds, such as four-cyclic compounds such as azetidine-2-one substitutes, and a number of five-cyclic compounds such as substitutes for each of the oxadiazole, thiadiazoles, triazoles, tetrazoles, thiazolidines, and pyrazoles. , As well as the preparation of a number of hexagonal ring substitutes represented by phthalazine and a number of seven-ring substitutes represented by oxazepine substitutes. Also, in this study, a number of polymers containing within their structures on heterocyclic five-ring parts such as oxadiazole and benzothiazole were prepared and characterized, using gradual growth polymerization such as polyamide Polyimine, polythioester, and polysulfide, By using two types of main monomers prepared, represented by benzo-bis (thiazole) diamine monomers, derived from the isomers of phenylenediamine and benzidine, and monomers 5,5ˋ-(substituted) bis (1,3,4-oxadiazole-2-thiol) derived from Three types of dicarboxylic acids.All the prepared compounds were characterized by infrared (IR) spectrometry, and some of them by both proton nuclear magnetic resonance (1H-NMR) and carbon-13 isotope (13C-NMR) and mass spectrometry, The inhibition effectiveness of a number of compounds prepared on two types of bacteria (Eschershia coil and Staphylococcus aureu) was also tested using the disc diffusion method, Which showed that some compounds possess good inhibitory activity against these types of bacteria, in addition to testing the viability of normal cells (HdFn) and cancer cells type (MCF-7) towards different concentrations of some compounds prepared by the (MTT) assay, which was shown by In which one of the phthalazine substitutes had strong activity against breast cancer cells (MCF-7) at high concentrations, with an almost safe effect on normal cells (HdFn) at all concentrations.The thermal stability of most of the prepared polymers was also evaluated by applying a thermogravimetric decomposition test (TGA) on them at a heating rate of (20 ºC/min) to a maximum of 600 ºC, as well as conducting electrical conductivity measurements for some of the prepared polymers that have successive lengths of polymeric chains. Using a locally manufactured electric cell in the College of Science, Department of Chemistry, University of Mosul, most of the polymers showed volumetric conductivity that falls within the electrical conductivity range of organic semiconductors.The Viva committee was chaired by Prof. Dr. Salem Jassim Muhammad Salih / University of Mosul / College of Science and the membership of Prof. Dr. Ghazwan Hassan Abdel Wahhab / Tikrit University / College of Education for Pure Sciences, Prof. Dr. Abdul Rahman Basil Fadel/University of Mosul / College of Science, Asst. Prof. Dr. Ragheed Yousef Ghazal / University of Mosul / College of Education for Pure Sciences, Asst. Prof. Dr. Yasser Shakib Muhammad / University of Mosul / College of Education for Pure Science and under the supervision and membership of both Asst. Prof. Dr. Mohanad Yaqdhan Saleh / University of Mosul / College of Education for Pure Science and Asst. Prof. Dr. Khaled Ahmed Owaid/ University of Mosul/ College of Education for Pure Science.