The Department of Chemistry at the College of Science, University of Mosul, discussed a distinguished Ph.D. dissertation on Thursday, March 26, 2026, entitled:

“Isolation and Molecular Study of Ferroportin Levels in Hemodialysis Patients and Its Relationship with Some Biochemical Variables”

submitted by the doctoral candidate Osama Younis Hamed Mohammed Al-Dulaimi.

The dissertation aimed to evaluate the levels of Ferroportin (FPN1) in hemodialysis patients and compare them with those of healthy individuals, with a particular focus on its vital role in regulating iron metabolism within the body. The study also investigated the relationship between ferroportin and several anemia-related factors, including erythropoietin, hepcidin, and erythroferrone, in addition to a range of biochemical markers associated with the disease condition.

The research included an advanced molecular analysis involving the assessment of gene expression levels of the SLC40A1 gene and the investigation of its role in regulating iron transport. Furthermore, potential genetic mutations were identified using DNA sequencing techniques. The researcher successfully identified a novel genetic mutation and deposited it in the GenBank database under accession number LC872842.1, following comparison with the reference sequence available in NCBI.

On the practical side, the researcher succeeded in isolating and purifying ferroportin protein from the serum of a healthy individual using advanced laboratory techniques and accurately determining its molecular weight. The study also evaluated the effects of several commonly prescribed medications for hemodialysis patients on ferroportin activity, aiming to identify their stimulatory or inhibitory effects and their significance in understanding drug interactions and iron homeostasis regulation.

The dissertation defense committee was chaired by Professor Dr. Luay Abdul Ali Al-Hilali and included a panel of specialized academics, under the supervision of Assistant Professor Dr. Eman Adel Hadi Al-Ramadan.

At the conclusion of the defense, the committee commended the scientific quality of the dissertation and its significant findings, which contribute to advancing biomedical and molecular research, particularly in the fields of kidney diseases, iron metabolism disorders, and associated anemia. The committee also emphasized the practical applicability of the results in developing improved diagnostic and therapeutic approaches.

This study aligns with Sustainable Development Goal 3 (Good Health and Well-Being) by contributing to a deeper understanding of the pathological mechanisms underlying chronic diseases, particularly kidney disorders and anemia-related conditions. The findings support the development of more accurate and effective diagnostic and treatment strategies, ultimately improving healthcare quality and reducing complications among patients.

Congratulations to the researcher on this achievement. We wish our dear students continued success, excellence, and further accomplishments in their academic and professional careers.

Media and Government Communication Division

Thursday, March 26, 2026